PRDX5 rabbit monoclonal antibody Overhead StirrersSpecification Full name PRDX5 rabbit monoclonal antibody Alternative names 50 l 100 l Reactivity rabbit monoclonal Applications WB, IHC Host Rabbit Clone type rabbit monoclonal Target Background This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under
temperature and humidity 5-40°C
and protein analysis workflows
Shown to inhibit the constitutive (IC50 = 40 nM in GTL16 cells) as well as HGF-stimulated (IC50 = 12 nM in A549 cells) MET autophosphorylation/activation in cultures in vitro and effectively suppress MET-dependent tumor growths in mice in vivo (twice daily oral dosings at 30 mg/kg)
The encoded protein is highly expressed in cancer cells and is induced by hypoxia
a phosphoprotein expressed in retina and pineal gland
The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway
Swissprot No P54687 Gene Accession BC033864 WB Predicted band size 43 kDa WB Positive control WB Recommended dilution 500-2000 IHC predicted cell location Predicted cell location: Cytoplasm IHC positive control Positive control: Human liver cancer IHC Recommed dilution Recommended dilution: 50-200 Storage
P112839-WB-1-P
Swissprot No Q9HAY2 Gene Accession NP_071432 WB Predicted band size 35 kDa WB Positive control WB Recommended dilution 500-2000 IHC predicted cell location Predicted cell location: Cytoplasm and Nucleus IHC positive control Positive control: Human brain IHC Recommed dilution Recommended dilution: 25-100 Storage
Mutations in this gene result in oculocutaneous albinism
with more colonies and positive rate of 100%
and antiviral activities
